Limitations of the ULTRA WGS (30x) test

It is important to be aware of the limitations of this technology:

• Not a diagnostic test. Results are informational, preventive, and for wellness purposes. Do not make clinical decisions without consulting a qualified healthcare professional. A genetic predisposition is not equivalent to a diagnosis.
• Variable coverage. Although the average coverage is 30x, there are regions of the genome that are difficult to sequence (highly repetitive areas, telomeres, centromeres), where reliability may be lower.
• Structural variant detection. These are detected with high reliability, but very small variants or those in complex regions may not be identified. Some large genetic expansions may require confirmation tests.
• Mosaicism. Low-level genetic mosaicism (presence of different cell populations in an individual) may not be detected.
• Mitochondrial DNA. Low-level heteroplasmies (mitochondrial variants) may go unnoticed.
• Ancestry. The accuracy of results depends on the representation of your population of origin in the reference databases.
• Pharmacogenetics. This report is not available in the U.S. Where it is available, recommendations should always be interpreted by a professional.